Dengue by Scott B. Halstead

By Scott B. Halstead

This designated quantity provides an updated evaluate of 1 of the area s significant illnesses -- illnesses because of the 4 dengue viruses. It starts with an insightful tale of the beginning of dengue illness outbreaks, together with the emergence of critical and deadly dengue hemorrhagic fever. The nature, constitution and biology of the 4 dengue viruses are defined, and a significant element of the publication is targeted at the epidemiology of dengue as a mosquito-borne affliction. this can be complemented by way of reviews of current mosquito regulate courses by means of 3 teams of exceptional specialists. The most powerful portion of the amount is its entire description of the present realizing of dengue disorder pathogenesis, through an research of the execs and cons of 5 of the main arguable components within the box: the WHO DEF case definition, secondary dengue infections, virulent viruses, the function of irregular T cells and autoimmunity.

Contents: Dengue: evaluate and background (S B Halstead); The Infectious Agent (D W C Beasley & A D T Barrett); Epidemiology (S B Halstead); Resistance to an infection (D W Vaughn et al.); scientific beneficial properties of Dengue (J Farrar); administration of Dengue (B Wills); Pathogenesis: possibility components ahead of an infection (S B Halstead); removing of an infection (A L Rothman & F A Ennis); Pathophysiology (S B Halstead); analysis of Dengue Virus Infections (T P Endy et al.); The keep an eye on of Dengue Vectors (N G Gratz & S B Halstead); organic keep watch over of Dengue Vectors: delivers from the previous (B H Kay); Mosquito keep watch over: Behavioral and neighborhood Interventions (P Winch et al.); Controversies (J Rigau-Perez et al.).

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Immunological parameters of togavirus disease syndromes. ) Togaviruses: Biology, Structure, Replication. Academic, New York, 1980, pp. 107–173. Lumley GF, Taylor FH. Dengue, School of Public Health and Tropical Medicine Service Publication No. 3. Glebe, NSW, Australia, 1943. Carey DE et al. Dengue viruses from febrile patients in Nigeria, 1964–68. Lancet 1971;1:105–106. Gubler DJ. Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. ) Dengue and Dengue Hemorrhagic Fever.

Causal hypotheses First impressions, 1958–62 In Thailand, there was a complication. A significant fraction of all hospitalized cases were caused by chikungunya, an alphavirus. Many patients with “Thai hemorrhagic fever” had simultaneous serological responses to dengue and chikungunya viruses. ” Early observations resulted in four hypotheses the causation of hemorrhagic fever: (1) “Hemorrhagic variants,” specifically dengue types 3–6, were responsible; (2) Role of chikungunya. In Thailand, as opposed to the Philippines, chikungunya, a nondengue virus, seemed to be causing up to 20% of cases.

46. 47. 48. 49. 50. Von Allmen SD et al. Epidemic dengue fever in Puerto Rico, 1977: a cost analysis. Am J Trop Med Hyg 1979;28:1040–1044. Okanurak K, Sornmani S, Indaratna K. The cost of dengue hemorrhagic fever in Thailand. Southeast Asian J Trop Med Public Health 1997b;28:711–717. Shepard DS et al. Cost-effectiveness of a pediatric dengue vaccine. Vaccine 2004;22:1275–1280. Murray CJL. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull World Health Organ 1994;72: 429–455.

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