Cytotoxic T-Lymphocytes in Human Viral and Malaria by M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

By M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

Cytotoxic T lymphocytes (CTL) keep watch over numerous viral infections in animals according to deletion and reconstitution experiments with CTL clones and use of CD8 genetically poor (knock-out) mice. during this quantity, info for the function that CTL play in human infectious ailments is gifted. As such, this represents the 1st quantity within which such info from a number of diversified viral and protozoan infections is introduced together.

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Extra resources for Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections

Example text

CTL and Immune Escape . . . . Inhibition of Human Immunodeficiency Vaccine-Related Issues. . . . . 5 Virus Structural Proteins. . . . . . . . . . . . . . . . . . . . . . . . . 35 . . . . . . . . . . .. .. 39 39 45 47 . . . . . CTL . . . . . . . . . . . . .. .. 51 52 52 54 55 Conclusions......................................... 56 References . . . . . . . . . . . . . . . . . . . . . . 57 . . . . . . . .

Ann Intern Med 108: 585-594 Jahn G, Scholl B-C, Traupe B, Fleckenstein B (1987) The two major structural phosphoproteins (pp65 and pp150) of human cytomegalovirus and their antigenic properties. J Gen Virol 68: 1327 -1337 Jordan MC, Shanley J D, Stevens JG (1977) Immunosuppression reactivates and disseminates latent murine cytomegalovirus. J Gen Virol 37: 419-423 Koszinowski UH, Keil GM, Schwarz H, Schickedanz J, Reddehase MJ (1987) A nonstructural polypeptide encoded by immediate early transcription unit I of murine cytomegalovirus is recognized by cytolytic T lymphocytes.

39 39 45 47 . . . . . CTL . . . . . . . . . . . . .. .. 51 52 52 54 55 Conclusions......................................... 56 References . . . . . . . . . . . . . . . . . . . . . . 57 . . . . . . . . . . . Virus Type . . . . . 1 . . . . . . . . . . . Replication . . . . . . . by . 1 Introduction Following the identification of the human immunodeficiency virus type 1 (HIV-1) as the etiologic agent of acquired immunodeficiency syndrome (AI DS; BARRE-SINOUSSI et al.

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