Chemokines and viral infection by Thomas E. Lane

By Thomas E. Lane

Chemokines signify a family members of over forty small proteins that, for the main half, are secreted into the surroundings and serve as by way of binding to G protein-coupled receptors (GPCRs) which are expressed on a number of varied mobile forms. while in the beginning pointed out as regards to 30 years in the past, those molecules have been linked to quite a few human inflammatory ailments and it was once famous that expression will be vital in leukocyte recruitment to infected tissue. inside of a comparatively brief time period, early individuals in the box decided that those proteins displayed specific and conserved structural beneficial properties and exerted powerful chemotactic results on outlined lymphocyte subsets. There at the moment are 4 sub-families of chemokines pointed out in accordance with outlined structural standards in terms of the positional situation of conserved cysteine residues in the amino-terminus of the protein. Chemokines are actually famous as very important in several organic techniques starting from preserving the organizational integrity of secondary lymphoid tissue to partaking in a variety of features of either innate and adaptive immune responses following microbial an infection.

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2 NK Cells and Antiviral Defenses . . . . . . . . . . . . . . . 31 NK Cell Responses in MCMV Infection . . . . . . . . . . . . . 32 NK Cell Inflammatory Responses in Liver During MCMV Infection . . . 3 CCL3/MIP-1α: Primary Mediator of NK Cell Inflammation . . . . . MIP-1α and Antiviral Defenses: The Cytokine and Chemokine Networks . The Type 1 Interferons (IFN-α/β) Association . . . . . . . . . . The CXCL9/Mig Association .

Hokeness Murine cytomegalovirus Natural killer Macrophage inflammatory protein 1α Monokine induced by interferon-γ Monocyte chemoattractant protein-1 Recombinant interferon-α 1 Introduction The host response to microbial pathogens necessitates the integrated action of both the innate and adaptive arms of the immune system. Innate immunity is largely dependent on granulocytes, macrophages, dendritic cells, and natural killer (NK) cells, whereas adaptive immune responses require T and B lymphocytes.

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