Antiviral Methods and Protocols (Methods in Molecular by Derek Kinchington, Raymond F. Schinazi

By Derek Kinchington, Raymond F. Schinazi

Skilled scientists describe-in an easily-followed format-their state of the art concepts for comparing antiviral compounds. The assays defined contain platforms for investigating medications used opposed to herpesviruses, hepatitis viruses, human immunodeficiency viruses, human papillomaviruses, and influenza viruses. those well-tested tools variety from mobile assays to a couple of the main updated molecular methods for opting for compounds which are lively opposed to viral enzymes and the improvement of viral resistance opposed to medications at the moment in use. well timed and entire, Antiviral tools and Protocols bargains modern-day researchers in academia, scientific departments, and the pharmaceutical the robust, reproducible, and novel tools had to evaluation compounds powerful opposed to either acute and protracted infections.

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Finally, some chapters describe the virological and biochemical assays that measure the resistance of viruses against one of the new generations of neuraminidase inhibitors. Production of volumes such as this are always flawed by the passage of time. However, we hope that it will provide a snapshot of the valuable and exciting work that continues in this area of science and be a significant aid to those involved in discovering new compounds. DEREK KINCHINGTON RAYMOND F. SCHINAZI Page vii CONTENTS Preface v List of Contributors xi 1 Changing Methods for Discovering Antiviral Drugs Philip S.

All cultures, stocks, and contaminated wastes must be decontaminated before disposal by an approved method, such as autoclaving. Materials to be decontaminated outside of the laboratory must be placed in a durable, leakproof container and closed for transport from the laboratory.

J. S. Mills and Dr. F. X. Wilson for critical reading of the manuscript. Page 12 References 1. Sneader, W. (1985) The human herpesviruses, in Drug Discovery: The Evolution of Modern Medicines, Wiley, New York, p. 292. 2. , Holsinger, L. , and Lamb, R. A. (1992) Influenza virus M2 protein has ion channel activity. Cell 69, 517528. 3. Sneader, W. (1985) Drug Discovery: The Evolution of Modern Medicines, Wiley, New York, p. 351. 4. Levine, A. J. (1992) Viruses, Scientific American Library, p. 74. 5.

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