Antibiotic Therapy for Geriatric Patients by Thomas T. Yoshikawa, Shobita Rajagopalan

By Thomas T. Yoshikawa, Shobita Rajagopalan

Written by way of the key professionals at the subject, this reference presents easy accessibility to crucial info on particular antibiotics, significant scientific infections, chosen pathogens, and infections in long term elderly-care facilities-summarizing the sizeable array of issues concerning infectious ailments in older adults together with epidemiology, medical manifestations, altered host resistance, and pharmacology.

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14. Bender BS, Scarpace P. Fever in the elderly. In: Mackowiak P, ed. Fever: Basic Mechanism and Management. Philadelphia, PA: Lippincott-Raven, 1997:363–373. 15. Knockaert DC, Vanneste LJ, Bobbaers HJ. Fever of unknown origin in the elderly patients. J Am Geriatr Soc 1993; 41:1187–1192. 16. Fein AM, Feinsilver SH, Niederman MS. Atypical manifestations of pneumonia in the elderly. Clin Chest Med 1991; 12:319–336. 17. Harper C, Newton P. Clinical aspects of pneumonia in the elderly veteran. J Am Geriatr Soc 1989; 37:867–872.

Publ Health Rep 1979; 94:203–209. 3. Weber DJ, Rutala WA. Biological basis of infectious disease epidemiology. In: Thomas JC, Weber DJ, eds. Epidemiologic Methods for the Study of Infectious Diseases. New York: Oxford University Press, 2001:3–27. 4. Lyons AS, Petrucelli RJ. Medicine: An Illustrated History. New York: Harry N. Abrams, 1978. 5. Kupersmith C. Three Centuries of Infectious Disease: An Illustrated History of Research and Treatment. Greenwich, Connecticut: Greenwich Press, 1998. 6. Pasteur L.

3. Altered Clinical Manifestations It has long been recognized that older persons commonly present with significant infection in the absence of classic signs. Definitions used in infectious disease epidemiology change secondary to differences in disease presentation of the elderly, and therefore knowledge of age-specific differences in presentation is essential to avoid selection and misclassification bias (17). Fever, the cardinal sign of infection, may be absent or blunted 20% to 30% of the time (18).

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