By Donna H. Wang
Donna Wang and a panel of hands-on specialists describe in step by step element the entire significant molecular, biochemical, and sensible suggestions now utilized in probing the renin-angiotensin procedure. those diversity from using embryonic gene concentrating on to create of mutant traces, to the sensible research of elements of the renin-angiotensin procedure. entire and hugely useful, Angiotensin Protocols interprets professional wisdom into effortlessly reproducible equipment that let all biomedical investigators effectively to discover the position of angiotensin in well-being and ailment this day.
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117, 845–853. 13. Myers, B. , Deen, W. , and Brenner, B. M. (1975) Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal fluid reabsorption in the rat. Circ. Res. 37, 101–110. 14. Mann, S. , Pickering, T. , Sos, T. , Uzzo, R. , et al. (1991) Captopril renography in the diagnosis of renal artery stenosis: accuracy and limitations. Am. J. Med. 90, 30–40. 15. Tullis, M. , Zierler, R. , Caps, M. , Bergelin, R. , and Strandness, D. , Jr. (1998) Clinical evidence of contralateral renal parenchymal injury in patients with unilateral atherosclerotic renal artery stenosis.
For example, the first description of the vasoconstrictor peptide endothelin and its amino acid sequence were published in the same paper (68) in 1988 and within a few years pharmacological antagonists of this system were developed. ” The reason for this is obvious—scientific discovery is based on previous work, and each new observation or new method spawns more research, more publications, and so forth. Our challenge for the next millennium will be to effectively utilize the technological advances that are taking place in virtually all areas of science.
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