Aging, Immunity, and Infection by Joseph F. Albright

By Joseph F. Albright

George Washington Univ. college of drugs, Washington, D.C. Examines the most important gains and services of the immune approach probably to be altered via the getting older procedure. stories the slow breakdown of the resistance to an infection within the elderly and discusses lifespan extension and dietary hold up of immunosenescence. DNLM: Immunity--Aged.

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The extreme variability, versatility, and adaptability of bacteria arise from two processes that are not found in eukaryotic organisms: (a) horizontal (lateral) transfer of genetic material (77); and (b) hypermutability associated with “mutator” strains (78,79). There are three mechanisms for delivering exogenous DNA into recipient bacteria: (a) transformation, which involves bacterial uptake of naked, ambient DNA; (b) transduction, in which new DNA is delivered by bacteriophages; and (c) conjugation, which requires physical contact between donor and recipient cells and, most frequently, transfer of a plasmid.

Aeruginosa: one is the lasR-lasI system and the other the rhlI-rhlR system. The product of the lasI gene directs the synthesis of 3OC12-HSL and the product of lasR, in the presence of a sufficient concentration of 3OC12-HSL, activates a set of virulence genes that includes rhlI and rhlR. The gene, rhlI, is responsible for a product that directs the synthesis of but-HSL, which is involved in the activation of virulence genes. , ref. 64). Some biofilms comprise a single species of bacteria in which case the signals utilized by that species must be distinguished from those of other species.

In the 1980s there was a resurgence of research prompted by the recognition that (a) TB was a prominent opportunistic infection among AIDS victims and (b) many cases of TB were caused by antibiotic-resistant organisms. Much has been learned in the last decade. There has been some debate concerning which experimental animal serves as a suitable model of human TB; and, further, as to whether or not aging experimental animals are more susceptible to Mycobacterium infections than young adults. It was reported that old mice were no more susceptible than young adults to M.

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